Paula Podest Ruiz, 39, and Carlos Ciuffardi Elorriga, 41, were recently joined together in matrimony at 36,000ft in a ceremony officiated by the Pope.
The pair were working on board an aircraft taking Francis from Santiago to Iquique during his three-day visit to Chile, when the magical moment happened.
Ruiz and Elorriga were married in a civil ceremony eight years ago, and had been planning a religious ceremony at their parish church, near Santiago.
But their plans were ruined when the church was destroyed in an 8.8 magnitude earthquake which also triggered a tsunami, killing 500 in total. While Pope Francis was on board on Thursday the pair asked him to bless the union.