Mr de Vries was the founder of Medidata Solutions, a clinical research company.
The other person killed in the crash was Thomas P. Fischer, 54. the founder of a family-run flight school and its head instructor.
Mr Bezos’ partner, Lauren Sanchez, called Mr de Vries’ death a “painful loss”.
“We got to know Glen de Vries, an incredible man, and his partner Leah last month”, she wrote on Instagram.
“Leah’s love for Glen was visible every time we saw them together. When he took off for space she gripped my hand so tight it hurt. Thinking of that moment today with a broken heart. Our deepest sympathies go out to Leah and Glen’s family, we are so saddened by the tragic news.”